Faculty Research: Deborah Chadee
ProfessorÌý
Postdoctoral Research Fellow, Massachusetts General Hospital and Tufts Medical Center
B.S., Ph.D. University of Manitoba, Canada
Office: Ìý Ìý Ìý ÌýÌýÌý BO3099DÌý
Phone No: Ìý 419.530.5077
Email: Ìý Ìý Ìý ÌýÌýÌý deborah.chadee@utoledo.edu
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Research Areas: Cancer; Cell Signaling.
Research
Mitogen-activated protein kinase (MAPK) signaling pathways respond to diverse stimuli and regulate biological processes such as proliferation, migration, differentiation and motility. Our studies are focused on the Mixed Lineage Kinases (MLKs), which are MAPK kinase kinases (MAP3Ks) that activate multiple MAPK pathways. The long-term research goals include deciphering how MLKs are regulated by growth factors and stress stimuli in normal and neoplastic cells, and determining how altered regulation of MLKs and MAPK signaling pathways affects proliferation, invasion, migration and apoptosis in cancer cells.